Berberis aristata is a deciduous evergreen herb indigenous to subtropical climates including India, Nepal, Asia and South America that has been used medicinally since ancient times in Ayurvedic and Chinese paradigms. Berberis aristata is considered to be one of the most medicinally significant herbs within the Berberis genus due to its broad therapeutic actions, mainly attributed to the alkaloid berberine. Within these traditional paradigms, such medicinal uses included as an antioxidant, blood sugar balancer, lipometabolic, anti-inflammatory, hepatoprotective and digestive supporting agent.

Evail™ Technology

Harnessing berberine’s therapeutic potential requires optimal absorption and delivery of a component that usually has suboptimal oral bioavailability due to enterocyte P-glycoproteins limiting its intestinal absorption. The Designs for Health Evail™ Process is specifically formulated to enhance the absorption of difficult to absorb ingredients such as berberine. It is manufactured using the Designs for Health Evail™ technology, which is an all-natural formulation that improves absorption and delivery. This process uses a proprietary blend of sustainable MCT oils, Quillaja and Annatto Tocotrienols without the use of potentially harmful surfactants.

 Antioxidant

Berberine has demonstrated antioxidant properties. Specifically, berberine reduces oxidative stress via significant superoxide and hydroxyl scavenging activity and by enhancing endogenous antioxidant system levels and activity (i.e. glutathione, glutathione peroxidase, superoxide dismutase).

Cardiovascular system health

Experimental and clinical evidence has shown berberine to have cardio-supportive and lipid metabolic-modulating effects. It helps to maintain cardiovascular system health, healthy blood lipids and cholesterol levels (particularly total cholesterol, low- and high-density lipoproteins and triglycerides) via several mechanisms. These include upregulating hepatic low-density lipoprotein receptor (LDLR) mRNA expression and protein levels, inhibiting lipogenesis and cellular lipid accumulation.

Blood glucose levels

The long traditional use of berberine for maintaining blood sugar in Ayurvedic and Chinese paradigms has been validated by current clinical evidence demonstrating its effects on glucose metabolism involving insulin-mimetic and- independent mechanisms. In particular, along with its antioxidant mechanisms, berberine helps support healthy blood glucose levels by stimulating glycolysis, activating glucokinase and glucose-6-phosphate dehydrogenase activity and the AMP-activated protein-kinase pathway, modulating insulin receptor activity, promoting insulin sensitization and muscle glucose uptake and beneficially modulating the gastrointestinal microbiome.

Directions for use

Adults: Take 2 capsules 3 times a day, or as professionally prescribed.

Allergen Information

• No added: Gluten, Soy, Dairy, Lactose, Soy, Seeds, Nuts, Egg, Yeast, Sesame.
• Free From: Artificial Colours, Artificial Flavours, Sorbates.

Considerations, contraindications:

• Contraindicated for use during pregnancy.
• May enhance the effects of medications that interfere with bilirubin protein binding.